AXL / UFO抗体

AXL / UFO抗体产品信息

免疫原 :
Recombinant mouse AXL protein ( Catalog#50126-M08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse AXL ( rM AXL ; Catalog#50126-M08H ; NP_033491.2 ; Met 1 - Pro 443 ). AXL specific IgG was purified by mouse AXL affinity chromatography.
AXL / UFO抗体背景综述
Mouse AXL receptor tyrosine kinase, also known as AXL, is a member of the receptor tyrosine kinase (RTKs) subfamily characterized by two Ig-like motifs and two fibronectin type III motifs in the extracellular domains. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. This receptor can mediate cell aggregation by homophilic binding. AXL is also involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.. The AXL gene is a chronic myelogenous leukemia-associated oncogene and associated with colon cancer and melanoma. The mouse AXL cDNA encodes an 888 aa precursor that includes an 18 aa signal sequence, a 427 aa extracellular domain, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain. The extracellular domains of mouse and human Axl share 81% aa sequence identity.
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