Human IL12A & IL12B Heterodime

Human IL12A & IL12B Heterodimer抗体产品信息

免疫原 :
Recombinant Human Human IL12A & IL12B Heterodimer protein (Catalog#CT011-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
068
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human Human IL12A & IL12B Heterodimer (rh Human IL12A & IL12B Heterodimer; Catalog#CT011-H08H; NP_000873.2 & NP_002178.2; Met1-Ser219 & Met1-Ser328).
Human IL12A & IL12B Heterodimer抗体Background
Interleukin-12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a 70 kDa disulfide-linked heterodimeric cytokine composed of a 35-kD subunit P35 and a 40-kD subunit P40, also designated as IL-12A (Interleukin-12 subunit alpha) and IL-12B (Interleukin-12 subunit beta). IL-12 is predominantly produced by macrophages and B lymphocytes and plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 is involved in the differentiation and development of Th1 cells, enhancement of natural killer cytolytic function and mitogenic effects, as well as induction of IFN-gamma during which it can synergize with other IFN-gamma inducers. The most powerful inducers of IL-12 production are bacteria, bacterial products and parasites. IL-12A shows significant sequence similarity to IL-6, G-CSF, and exerts biological activities only when the IL-12B is co-expressed. IL-12B deficient mice are resistant to the induction of experimental chronic inflammatory diseases whereas IL-12A knock-out mice develop more severe forms, suggesting opposite functions of the two subunits in the outcome of chronic inflammatory diseases.
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