PARP1 / PARP-1抗体

PARP1 / PARP-1抗体产品信息

免疫原 :
Recombinant human PARP1 protein ( Catalog#11040-H08B )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human PARP1 ( rh PARP1 ; Catalog#11040-H08B ; NP_001609.2 ; Met 1 - Trp 1014 ). PARP1 specific IgG was purified by human PARP1 affinity chromatography.
PARP1 / PARP-1抗体 Background
Poly (ADP-ribose) polymerase 1 (PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. The poly(ADP-ribosyl)ation modification is critical for a wide range of processes, including DNA repair, regulation of chromosome structure, transcriptional regulation, mitosis and apoptosis. PARP1 is demonstrateed to mediate the poly(ADP-ribose) ation of APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains), two representative proteins involved in the DNA damage response and checkpoint regulation. Further, It has been suggested that DNA-dependent protein kinase (DNA-PK), another component of DNA repair, suppresses PARP activity, probably through direct binding and/or sequestration of DNA-ends which serve as an important stimulator for both enzymes. PARP1 inhibitors is thus proposed as a targeted cancer therapy for recombination deficient cancers, such as BRCA2 tumors.
PARP1 / PARP-1抗体相关产品如下：
hz-2217hz Integrin alpha E2 peptide整合素alpha E2抗原
hz-1014hz Mac-1 (Mac-1/CR3/CD11b+CD18)巨噬细胞表面分子抗原
hz-0924hz Mafa(avian)(V-maf musculoaponeurotic fibrosarcoma oncogene homolog A)v-maf 肌腱膜纤维肉瘤癌基因同源物A抗原
hz-0817hz MAGE-1黑色素瘤相关
hz-1041hz MAPKK1 (MAP kinase kinase 1)丝裂原活化蛋白激酶激酶1抗原
hz-1425hz ASK1/MAPKKK5细胞凋亡信号调节激酶1/丝裂原活化蛋白激酶激酶激酶5抗原
hz-0792hz Maspin (mammary serine protease inhibitor)抑癌基因抗原
hz-0531hz Matriptase蛋白裂解酶（一种新的癌基因）抗原
hz-0808hz HCMV UL49(Human Cytomegalovirus UL49 Gene)人巨细胞病毒UL49抗原
hz-1419hz MC-1R (melanocortin-1-receptor)黑皮质素-1受体抗原
hz-1352hz Mcl-1(myeloid cell leukemia 1) peptide髓样细胞白血病-1抗原
hz-1468hz MDR1(multidrug resistance 1)多药耐药蛋白抗原
hz-1400hz MEF2(myocyte enhancer-binding factor 2)肌细胞增强因子2抗原
hz-0557hz Mfn1 (Mitofusin1)线粒体融合蛋白1
hz-1328hz MT(metallothionein)金属硫蛋白抗原
hz-0900hz MGr1-Ag/37LRP(P37-kDa laminin receptor precursor)层粘连蛋白受体1抗体
hz-0901hz MGr1-Ag/37LRP(P37-kDa laminin receptor precursor)(CT)层粘连蛋白受体1抗原（C端）
hz-1849hz MK(Midkine)中期因子/肝素结合生长因子抗原
hz-2240hz MLC/Myosin light chain 3 peptide肌球蛋白轻链3抗原
hz-1044hz MIF (Macrophage Migration Inhibitory Factor)巨噬细胞移动抑制因子抗原
hz-1046hz MIP-1 Beta (macrophage inflammatory protein 1 Beta)巨噬细胞炎症因子1β 抗原
hz-1959hz CD122/IL-2RB(Imterleukm-2 Receptor beta)CD122/白介素2受体β链抗原
hz-1162hz MIP2 (myocardial ischemic preconditioning upregulated protein 2)巨噬细胞炎症蛋白2抗原
hz-0575hz MMP-13 (Matrix metalloproteinase 13)基质金属蛋白酶13抗原
hz-0985hz MMP-20(matrix metalloproteinase 20)基质金属蛋白酶20抗原
hz-1862hz MMP-17(Matrix metalloproteinase-17)基质金属蛋白酶-17抗原
hz-1377hz MMP-26(Matrix metalloproteinase-26)基质金属蛋白酶-26抗原
hz-2099hz MMP-9(matrix metalloproteinase 9)基质金属蛋白酶-9抗原
hz-1344hz MMP-10(matrix metalloproteinase 10)基质金属蛋白酶-10抗原
hz-1061hz MPO peptide髓过氧化物酶抗原
hz-1092hz MRP2 (multidrug resistance-associated protein2)多药耐药相关蛋白2
hz-1437hz MRP5/ABCC5(Multidrug Resistanec-Associated Protein 5)多药耐药相关蛋白5抗原
hz-0818hz MrpL28 (mitochondrial ribosomal protein L28)线粒体核糖体蛋白L28(抗原)
hz-0836hz MLH1(Mutl homolog l gene)错配修复蛋白1抗原
hz-1022hz MUC5AC/Mucin 5AC(Gastric Mucin M1)胃粘液素抗原
hz-0963hz MTNR1B/MTNR-1B(Melatonin receptor 1B)褪黑素受体1B抗原