THY1 / CD90抗体

THY1 / CD90抗体产品信息

免疫原 :
Recombinant mouse THY1 protein ( Catalog #50461-M08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse THY1 ( rM THY1 ; Catalog #50461-M08H ; NP_033408.1 ; Met 1 - Cys 131 ). THY1 specific IgG was purified by mouse THY1 affinity chromatography
THY1 / CD90抗体 Background
Mouse Thy-1 membrane glycoprotein, also known as Thy-1 antigen, CD90 and THY1, is a cell membrane protein which contains 1 Ig-like V-type (immunoglobulin-like) domain. THY1 / CD90, a member of the immunoglobulin superfamily of adhesion molecules with constitutive expression on fibroblast cells. THY1 / CD90 is a cell surface glycoprotein originally identified on mouse thymocytes. It has been identified on a variety of stem cells and at varying levels in non-lymphoid tissues such as on fibroblasts, brain cells, and activated endothelial cells. THY1 / CD90 is a membrane glycoprotein expressed in thymus, retinal ganglionic cells, and several types of stem cells. It was observed that THY1 / CD90 cell surface expression decreased significantly during the course of infection. In adult rats, expression of THY1 / CD90 on the B cell lineage is confined to immature B cells. The expression of THY1 / CD90 on neonatal MZ-B cells may have implications for their responsiveness to polysaccharide (T cell-independent type 2) antigens. THY1 / CD90 is modulated following infection with Human cytomegalovirus (HCMV). Neuroblastoma (NBL) is the most common solid tumor in children. THY1 / CD90 seemed to be a marker with a specific prognostic value in NBL patients. THY1 / CD90 may also play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
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