TRAILR2 / TNFRSF10B抗体

TRAILR2 / TNFRSF10B抗体产品信息

免疫原 :
Recombinant mouse TNFRSF10B protein ( Catalog#50412-M08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse TNFRSF10B ( rM TNFRSF10B ; Catalog#50412-M08H ; NP_064671.2 ; Met 1 - Ser 177 ). TNFRSF10B specific IgG was purified by mouse TNFRSF10B affinity chromatography
TRAILR2 / TNFRSF10B抗体背景综述
Mouse TRAILR2, also known as DR5 and TNFRSF10B, is the fifth death domain–containing member of the TNFR family and a receptor for TRAIL/TNFSF10. TRAILR2 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a predicted hydrophobic transmembrane segment and a 209 aa long cytoplasmic tail containing a typical “death domain”. Upon ligand binding, the adapter molecule FADD recruits caspase-8 to the activated receptor TNFRSF10B. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. TRAIL-R2 exhibits high structural and functional homology to TRAIL-R1 (DR-4), and TNFRSF10B expression is regulated by the tumor suppressor p53. Further, it is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
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