ADIPOQ / ACDC / Adiponectin抗体

ADIPOQ / ACDC / Adiponectin抗体产品信息

免疫原 :
Recombinant mouse ADIPOQ protein ( Catalog#50636-M08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse ADIPOQ ( rM ADIPOQ ; Catalog#50636-M08H ; NP_033735.3 ; Met 1 - Asn 247 ). ADIPOQ specific IgG was purified by mouse ADIPOQ affinity chromatography
ADIPOQ / ACDC / Adiponectin抗体背景综述
Mouse adiponectin, also known as Adipocyte, C1q and collagen domain-containing protein, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, gelatin-binding protein, ADIPOQ and ACDC, is a secreted protein which contains one C1q domain and one collagen-like domain. ADIPOQ / ACDC is an important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. ADIPOQ / ACDC stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. ADIPOQ / ACDC antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. ADIPOQ / ACDC inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. It may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
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