CLIC4 抗体

CLIC4 抗体产品信息

免疫原 :
Recombinant Human CLIC4 protein (Catalog#12271-H07E)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human CLIC4 (rh CLIC4; Catalog#12271-H07E; Q9Y696-1; Ala 2-Lys 253). CLIC4 specific IgG was purified by Human CLIC4 affinity chromatography.
CLIC4 抗体 Background
Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains oneGST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. CLIC4 could promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Expression of CLIC4 is prominent in heart, kidney, placenta and skeletal muscle. Overexpression of CLIC4 in cancer cells inhibits tumor growth. Conversely, overexpression of CLIC4 in tumor stromal cells stimulates tumor growth. Thus, CLIC4 participates in normal and pathological processes and may serve as a useful target for therapies in disturbances of homeostasis and neoplastic transformation. Loss of CLIC4 in tumor cells and gain in tumor stroma is common to many human cancers and marks malignant progression. Up-regulation of CLIC4 in tumor stroma is coincident with myofibroblast conversion, generally a poor prognostic indicator. Reactivation and restoration of CLIC4 in tumor cells or the converse in tumor stromal cells could provide a novel approach to inhibit tumor growth.
CLIC4 抗体相关产品如下：
hz-1553R Claudin 5紧密连接蛋白5抗体
hz-4266R Cip4细胞分化周期CDC42相互作用蛋白4抗体
hz-5747R CDKL3细胞周期蛋白依赖性激酶样3抗体
hzm-2079M Cecropin杀菌肽/天蚕抗菌肽单克隆抗体
hz-13685R C17orf87第十七号染色体开放阅读框87抗体
hz-10516R Calcitonin receptor降钙素受体抗体
hz-10428R C2a补体C2a链多肽抗体
hz-10340R CD80CD80抗体
hz-10358R CD19CD19抗体
hz-15512R CCL26C-C元件趋化因子26抗体
hz-15200R C5orf225号染色体开放阅读框22抗体
hz-15511R CLCA4钙激活氯离子通道4蛋白抗体
hz-10409R CCL26 Signal peptide嗜酸粒细胞趋化蛋白3抗体
hz-15513R CCL26嗜酸粒细胞趋化蛋白3抗体
hz-10410R chemerin趋化素抗体
hz-15211R C5orf55 5号染色体开放阅读框55抗体
hz-2555R CXCR7细胞表面趋化因子受体7抗体
hz-2562R COX7A2细胞色素c氧化酶7A2抗体
hz-8873R CD36CD36抗体
hz-10161R CYP11B2醛固酮合成酶CYP11B2抗体
hz-15259R C7orf167号染色体开放阅读框16抗体
hz-9769R C10orf6210号染色体开放阅读框62抗体
hz-12423R CAPRIN2胃癌多药耐药相关蛋白
hz-12427R Caseine Kinase 1 alpha酪蛋白激酶casein kinase Iα抗体
hz-12428R phospho-Caseine Kinase 1 alpha(Tyr294)磷酸化酪蛋白激酶casein kinase Iα抗体
hz-12429R phospho-Caseine Kinase 1 alpha (Thr1194)磷酸化酪蛋白激酶casein kinase Iα抗体
hz-12445R Actin Regulatory Protein CAPG肌动蛋白调节蛋白CAPG抗体
hz-7158R Collagen IⅠ型胶原/1型胶原a1抗体
hz-7322R Collagen IIIⅢ型胶原蛋白/胶原蛋白3/3型胶原蛋白抗体
hz-12187R CD96CD96抗体
hz-13824R CECR2猫眼综合征染色体候选基因2抗体
hz-15024R C1orf1461号染色体开放阅读框146抗体
hz-15028R C1orf150 1号染色体开放阅读框150抗体
hz-15030R C1orf156 1号染色体开放阅读框156抗体
hz-15031R C1orf1591号染色体开放阅读框159抗体
hz-15032R C1orf162 1号染色体开放阅读框162抗体
hz-15033R C1orf1631号染色体开放阅读框163抗体
hz-15011R C1orf122 1号染色体开放阅读框122抗体
hz-15012R C1orf1231号染色体开放阅读框123抗体
hz-15013R C1orf1241号染色体开放阅读框124抗体
hz-15014R C2orf3 2号染色体开放阅读框3抗体
hz-15015R C1orf1271号染色体开放阅读框127抗体
hz-15016R C1orf1291号染色体开放阅读框129抗体
hz-15017R C1orf1301号染色体开放阅读框130抗体
hz-15018R C1orf1311号染色体开放阅读框131抗体
hz-15019R C1orf1351号染色体开放阅读框135抗体
hz-15021R C1orf1411号染色体开放阅读框141抗体
hz-15022R C1orf1441号染色体开放阅读框144抗体
hz-12464R alpha COP ICOPA蛋白抗体