Ephrin-B1 / EFNB1抗体

Ephrin-B1 / EFNB1抗体产品信息

免疫原 :
Recombinant Mouse Ephrin-B1 / EFNB1 protein (Catalog#50580-M08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Mouse Ephrin-B1 / EFNB1 (rM Ephrin-B1 / EFNB1; Catalog#50580-M08H; NP_034240.1; Met 1-Ser 229). Ephrin-B1 / EFNB1 specific IgG was purified by Mouse Ephrin-B1 / EFNB1 affinity chromatography.
Ephrin-B1 / EFNB1抗体Background
The ephrins (Eph) and Eph receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. Inmolecular biology,ephrins and Eph receptors are components of cell signaling pathways involved in animal development, and implicated in some cancers. Mouse ephrin-B1, also known as LERK-2, ELK-L, EFL-3, Cek5-L, and STRA-1, is a member of the ephrin ligand family which binds members of the Eph receptor family. Ephrin-B1 has been shown to bind EphA3, EphB1, EphB2, EphB3, and EphB4. The extracellular domains of human and mouse ephrin-B1 share 94% amino acid identity.
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