JAM-2 / JAM-B抗体

JAM-2 / JAM-B抗体产品信息

免疫原 :
Recombinant Mouse JAM-2 / JAM-B protein (Catalog#50464-M08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Mouse JAM-2 / JAM-B (rM JAM-2 / JAM-B; Catalog#50464-M08H; NP_076333.3; Met 1-Asn 236). JAM-2 / JAM-B specific IgG was purified by Mouse JAM-2 / JAM-B affinity chromatography.
JAM-2 / JAM-B抗体 Background
Junctional adhesion molecule B, also known as Junctional adhesion molecule 2, Vascular endothelial junction-associated molecule, CD322 and JAM2, is a single-pass type I membrane protein which belongs to theimmunoglobulin superfamily. JAM2 contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. Highest expression of JAM2 is in the heart, placenta, lung, foreskin and lymph node. It is prominently expressed on high endothelial venules. It is also present on the endothelia of other vessels. JAM2 is Localized to the intercellular boundaries of high endothelial cells. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. JAM2 is localized in the tight junctions between high endothelial cells. JAM2 acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
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