JAM-3 / JAM-C抗体

JAM-3 / JAM-C抗体产品信息

免疫原 :
Recombinant Mouse JAM-3 / JAM-C protein (Catalog#50465-M08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Mouse JAM-3 / JAM-C (rM JAM-3 / JAM-C; Catalog#50465-M08H; NP_075766.1; Met 1-Asn 241). JAM-3 / JAM-C specific IgG was purified by Mouse JAM-3 / JAM-C affinity chromatography.
JAM-3 / JAM-C抗体Background
Junctional adhesion molecule C, also known as Junctional adhesion molecule 3, JAM3, is a single-pass type I membrane protein which belongs to theimmunoglobulin superfamily. JAM3 is widely expressed. The highest expression of JAM3 is in placenta, brain and kidney. JAM3 contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. At the protein level JAM3 displays 36 and 32% identity to JAM2 and JAM1, respectively. JAM3 participates in cell-cell adhesion distinct from tight junctions. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. JAM3 is localized in the tight junctions between high endothelial cells. Unlike other proteins in the same family, this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions.
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