BETA-BUNGAROTOXIN B CHAIN FROM

银环蛇霉素bungarotoxin

银环蛇霉素 bungarotoxin 为产于东南亚的毒蛇 Bungarus multicinctus的蛇毒，含有数种神经毒素。其中α -银环蛇毒素（分子量 7983）因与突触后侧的烟碱性乙酰胆碱受体发生特异的结合。所以可切断神经肌肉接点的突触传递；而β -银环蛇毒素（ A链分子量为 13500， B链分子量为 7000），由于可抑制神经末梢小体释放传递物质。所以影响突触传导。β -银环蛇毒素具有强烈的磷酸酶 A2 活性，但只有在有钙离子存在的条件下才显活性。此外还有 r-银环

One‐Step Vital Staining of Presynaptic Terminals and Post‐Synaptic Receptors at Neuromuscular Junctions in Mouse Skeletal Muscle

. Neurosci. Methods 71:3‐9.    Chang, C.C. and Lee, C.Y. 1963. Isolation of neurotoxins from the venom of Bungarus multicinctus and their modes of neuromuscular blocking action. Arch

CD49a/CD49b/CD49c/CD49d/CD49e/CD49f分子

1 chain Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Very late activation proteins (VLA) are a family of integrins