VASN / Vasorin抗体

VASN / Vasorin抗体产品信息

免疫原 :
Recombinant Human VASN / Vasorin protein (Catalog#13854-H08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human VASN / Vasorin (rh VASN / Vasorin; Catalog#13854-H08H; Q6EMK4; Met1-Pro575). Total IgG was purified by Protein A affinity chromatography.
VASN / Vasorin抗体 Background
Vasorin contains tandem arrays of a characteristic leucine-rich repeat motif, an epidermal growth factor-like motif, and a fibronectin type III-like motif at the extracellular domain. It is a type I membrane protein that is expressed predominantly in vascular Smooth muscle cells. Vasorin directly binds to TGF-beta and attenuates TGF-beta signaling in vitro. This suggests that down-regulation of vasorin expression contributes to neointimal formation after vascular injury and that vasorin modulates cellular responses to pathological stimuli in the vessel wall. It may act as an inhibitor of TGF-beta signaling. Vasorin interacts with TGFB1, TGFB2 and TGFB3.
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