CD32a / FCGR2A抗体

CD32a / FCGR2A抗体产品信息

Immunogen:
Recombinant human CD32a protein ( Catalog#10374-H08H )
Clone ID:
2C3B11B8
Ig Type: Mouse IgG1
缓冲液: 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation:
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human CD32a extracellular domain ( rhCD32a; Catalog#10374-H08H; aa 1-218; NP_001129691.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CD32a / FCGR2A抗体 Background
Receptors that recognize the Fc portion of IgG (Fcγ Rs) functions in the regulation of immune response and are divided into three classes designated Fcγ RI (CD64), Fcγ RII (CD32), and Fcγ RIII (CD16). Fcγ RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Human CD32 class is divided into three closely related proteins, and designated FcγRIIA (CD32a), FcγRIIB (CD32b), and FcγRIIC (CD32c). They share 94-99% amino acid identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. CD32a is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. CD32a delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production.
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