Thrombopoietin / THPO抗体

Thrombopoietin / THPO抗体产品信息

免疫原 :
Recombinant Cynomolgus Thrombopoietin / THPO protein (Catalog#90004-C08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Cynomolgus Thrombopoietin / THPO (rCynomolgus Thrombopoietin / THPO; Catalog#90004-C08H; Met 1-Gly 353). Thrombopoietin / THPO specific IgG was purified by Cynomolgus Thrombopoietin / THPO affinity chromatography.
Thrombopoietin / THPO抗体 Background
Thrombopoietin (THPO) is a hematopoietic growth factor that is involved in the regulation of platelet production. This cytokine is composed of an amino-terminal erythropoietin-like domain which is the functional domain and a highly glycosylated carboxyl domain that appears to stabilize circulating thrombopoietin. THPO stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. It has been identified that surface c-MPL, the receptor for THPO, binds to the ligand and mediates the action. THPO has multilineage effects in hematopoiesis, not only stimulating megakaryocytopoiesis but also acting in synergy with other cytokines to enhance proliferation and survival of committed erythroid progenitors and primitive hematopoietic stem cells. Mouse THPO is found mainly in the liver, kidney and skeletal muscle.
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