IL17RA / CD217抗体

IL17RA / CD217抗体产品信息

免疫原 :
Recombinant human IL17RA protein ( Catalog# 10895-H08H )
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
8E6B9F4
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human IL17RA ( rh IL17RA ; Catalog#10895-H08H ; NP_055154.3 ; Met 1 - Trp 320 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
IL17RA / CD217抗体Background
IL17RA ( Interleukin 17 receptor A ), also known as IL17R and CDw217, is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A (IL17A). IL17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL17A binds to a type I cell surface receptor called IL17R of which there are at least three variants IL17RA, IL17RB, and IL17RC. IL17RA is a widely expressed glycoprotein that plays a central role in inflammatory responses. IL17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. Human IL17RA is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of human IL17RA is 69% identical to the mouse IL17R. Within the extracellular domain, human IL17RA shares 72% aa sequence identity with mouse and rat IL17RA. IL17RA associates with IL17RC to form a signaling receptor complex for IL17 and IL17F. Ligand and IL17RA ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines.
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