BMP-2抗体

BMP-2抗体产品信息

免疫原 :
Recombinant Human BMP-2 protein (Catalog#10426-HNAE)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
7D10G8E2
抗体宿主 :
Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BMP-2 (rh BMP-2; Catalog#10426-HNAE; NP_001191.1; Gln 283-Arg 396). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
BMP-2抗体Background
Bone morphogenetic protein 2 (BMP2) is a member of the BMP subgroup belonging to the transforming growth factor (TGF)-beta superfamily. The mature BMP2 acts as disulfide-linked homodimers and heterodimers with BMP-7 after proteolytic removal of propeptide. BMP2 is capable of inducing the formation of cartilage and bone but are now regarded as multifunctional cytokines. It binds heterodimeric receptor complexes composed of a type I receptor and a type II receptor, and transduces the related signals via the down-stream molecules, such as the PI3 kinase, Smads, STATs, etc. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function. In addition, recent studies have revealed that osteoblast-derived BMP2 enhances the migration of prostate cancer cells. rhBMP2 can be utilized in various therapeutic interventions such as bony defects, delayed union, non-union fractures and osteoporosis.
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