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FCGRT & B2M Heterodimer (FcRn)抗体
FCGRT & B2M Heterodimer (FcRn)抗体产品信息
免疫原 :
Recombinant Human FCGRT & B2M Heterodimer (FcRn) protein (Catalog#CT009-H08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human FCGRT & B2M Heterodimer (FcRn) (rh FCGRT & B2M Heterodimer (FcRn); Catalog#CT009-H08H; P55899 & P61769; Met1-Ser297 & Met1-Met119). FCGRT & B2M Heterodimer (FcRn) specific IgG was purified by Human FCGRT & B2M Heterodimer (FcRn) affinity chromatography.
FCGRT & B2M Heterodimer (FcRn)抗体 Background
IgG receptor FcRn large subunit p51, also known as IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, FCGRT and FCRN, is a single-pass type I membrane protein which belongs to theimmunoglobulin superfamily. FcRn / FCGRT is a MHC class I like molecule that functions to protect IgG and albumin from catabolism. FcRn / FCGRT binds to the Fc region of monomeric immunoglobulins gamma. It mediates the uptake of IgG from milk. It may play a role in transfer of immunoglobulin G from mother to fetus.
Beta-2-microglobulin, also known as B2M, is a secreted protein which belongs to thebeta-2-microglobulin family. It contains oneIg-like C1-type (immunoglobulin-like) domain. Beta-2 microglobulin (B2M) plays a pivotal role in the biology of mammals. B2M forms the small invariable light chain subunit of class I HLA antigens on the cell membrane of all nucleated cells. During the continuous turnover of the HLA molecules. B2M is shed from the cell membrane into blood. Lymphocytes are the main source of serum free B2M. It associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules. B2M is necessary for cell surface expression of MHC class I and stability of the peptide binding groove. In fact, in the absence of B2M, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface.
FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin (B2M). It forms an MHC class I-like heterodimer. B2M is a component of the class I major histocompatibility complex (MHC). B2M is also an integral component of the FcRn heterodimer. Failure of passive transfer (FPT) is a condition in which neonates do not acquire protective serum levels of maternal antibodies. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog (FcRn) and beta-2-microglobulin (B2M).
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免疫原 :
Recombinant Human FCGRT & B2M Heterodimer (FcRn) protein (Catalog#CT009-H08H)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human FCGRT & B2M Heterodimer (FcRn) (rh FCGRT & B2M Heterodimer (FcRn); Catalog#CT009-H08H; P55899 & P61769; Met1-Ser297 & Met1-Met119). FCGRT & B2M Heterodimer (FcRn) specific IgG was purified by Human FCGRT & B2M Heterodimer (FcRn) affinity chromatography.
FCGRT & B2M Heterodimer (FcRn)抗体 Background
IgG receptor FcRn large subunit p51, also known as IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, FCGRT and FCRN, is a single-pass type I membrane protein which belongs to theimmunoglobulin superfamily. FcRn / FCGRT is a MHC class I like molecule that functions to protect IgG and albumin from catabolism. FcRn / FCGRT binds to the Fc region of monomeric immunoglobulins gamma. It mediates the uptake of IgG from milk. It may play a role in transfer of immunoglobulin G from mother to fetus.
Beta-2-microglobulin, also known as B2M, is a secreted protein which belongs to thebeta-2-microglobulin family. It contains oneIg-like C1-type (immunoglobulin-like) domain. Beta-2 microglobulin (B2M) plays a pivotal role in the biology of mammals. B2M forms the small invariable light chain subunit of class I HLA antigens on the cell membrane of all nucleated cells. During the continuous turnover of the HLA molecules. B2M is shed from the cell membrane into blood. Lymphocytes are the main source of serum free B2M. It associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules. B2M is necessary for cell surface expression of MHC class I and stability of the peptide binding groove. In fact, in the absence of B2M, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface.
FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin (B2M). It forms an MHC class I-like heterodimer. B2M is a component of the class I major histocompatibility complex (MHC). B2M is also an integral component of the FcRn heterodimer. Failure of passive transfer (FPT) is a condition in which neonates do not acquire protective serum levels of maternal antibodies. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog (FcRn) and beta-2-microglobulin (B2M).
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hz-15145R C2GNT3C2GNT3蛋白抗体
hz-5460R phospho-c-Jun(Thr239)磷酸化原癌基因c-Jun抗体
hz-5462R phospho-c-Jun(Thr249)磷酸化原癌基因c-Jun抗体
hz-15590R CYFRA21-1 肿瘤标志物CYFRA21-1抗体
hz-5458R phospho-c-Jun(Thr91)磷酸化原癌基因c-Jun抗体
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hz-4602R CD8CD8/CD8-β抗体
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hz-4614R ICAM1细胞间粘附分子-1抗体
hz-4615R ICAM1细胞间粘附分子1抗体
hz-4616R ICAM1细胞间粘附分子-1抗体
hz-4617R ICAM1细胞间粘附分子-1抗体
hz-4618R ICAM1细胞间粘附分子-1抗体
hz-7624R Cyclophilin F亲环蛋白（亲环素）PPIF抗体
hz-6874R Catalase过氧化氢酶抗体
hz-7098R CLIC4细胞内氯离子通道蛋白4抗体
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hz-7102R CCDC139卷曲螺旋结构域蛋白139抗体
hz-6375R CHMP1A染色体修饰蛋白1抗体（金属蛋白酶1）
hz-11812R CAPS1钙依赖分泌激活蛋白1抗体
hz-11814R CBLN1小脑肽1抗体
hz-11815R CBLN2小脑肽2抗体
hz-11816R CBLN4小脑肽4抗体
hz-11817R CCM2脑海绵状血管畸形蛋白2抗体
hz-11818R CELSR2表皮生长因子样蛋白2抗体
hz-11819R CHRDL1脊索生成素样蛋白1抗体
hz-11820R CHURC1神经诱导胚胎发育相关蛋白Churchill抗体
hz-11821R CRMP3二氢嘧啶酶相关蛋白3抗体
hz-11427R CRSP9转录激活蛋白CRSP9抗体
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hz-11416R Cpt1c脑型肉碱棕榈酰转移酶1C抗体
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hz-11830R CA10碳酸酐酶10抗体
hz-6953R CD62LL选择素抗体
hz-4963R C-Myc致癌基因C-Myc抗体
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FCGRT & B2M Heterodimer (FcRn)抗体
询价
