CD21抗体

CD21抗体产品信息

免疫原 :
Recombinant Human CD21 protein (Catalog#10811-H08H)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
5G8G3
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD21 (rh CD21; Catalog#10811-H08H; P20023-1; Met 1-Arg 971). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
CD21抗体 Background
Complement receptor type 2, also known as Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor, CD21 and CR2, is a single-pass type I membrane protein which belongs to thereceptors of complement activation (RCA) family. CD21 is tightly related to LFA-1 expression in (B-cell lymphoma) BCL and the absence of CD21 / LFA-1 expression is associated with pleural/peritoneal fluid involvement by BCL, a potential indicator of disease progression of BCL. CD21 / CR2 contains 15sushi (CCP/SCR) domains. CD21 / CR2 is a receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. CD21 / CR2 participates in B lymphocytes activation. Genetic variations in CD21 / CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
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