CD21分子
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CD21 分子
CD21
常用单克隆抗体或代号： B2,OKB- 1;(CR2)
主要表达细胞： Pre- B,B,FDC [B]
分子质量(kDa)和结构： p145(RCA)
功 能： C3d/EBV受体,B细胞活化,结合sCD23,信号转导
CD21
Aka CR2, C3d receptor, EBV receptor
Binds to Epstein Barr virus and breakdown products of complement component C3
Forms a signaling complex with CD19, CD81 and CD225
Both CD21 and CD23 are dendritic cell markers
Hodgkin’s lymphoma demonstrates disruption of follicular dendritic cell-germinal cell clusters (evaluated by CD21 and CD23)
Positive staining (normal): Mature B cells, follicular dendritic cells
Micro images (AJSP subscribers): inflammatory pseudotumor-like follicular dendritic cell tumor A, B, Hodgkin’s lymphoma A, B
Micro images (Mod Path subscribers): extranodal follicular dendritic cell sarcoma
References: AJSP 2001;25:721, AJSP 2001;25:388, Mod Path 2002;15:50
