IL-1R8 / IL1RAPL1抗体

IL-1R8 / IL1RAPL1抗体产品信息

免疫原 :
Recombinant Human IL-1R8 / IL1RAPL1 protein (Catalog#10177-H08H)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
2E10E1F5
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-1R8 / IL1RAPL1 (rh IL-1R8 / IL1RAPL1; Catalog#10177-H08H; NP_055086.1; Met 1-Leu 354). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
IL-1R8 / IL1RAPL1抗体 Background
IL1-receptor accessory protein-like 1 (IL1RAPL1), also known as IL1R8, a member of interleukin-1/toll like receptor (TIR) family, is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). The protein structurally comprises three extracellular immunoglobulin domains, which presumably mediate binding of an as yet unidentified ligand, a transmembrane region, and an intracellular domain, which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 150 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1), a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is suggested to affect human cognitive ability to some extent, especially the memory and concentration capability.
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