SIRPG / SIRP gamma / CD172g抗体

SIRPG / SIRP gamma / CD172g抗体产品信息

免疫原 :
Recombinant Human SIRPG / SIRP gamma / CD172g protein (Catalog#11828-H08H)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
1H7C2
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SIRPG / SIRP gamma / CD172g (rh SIRPG / SIRP gamma / CD172g; Catalog#11828-H08H; NP_061026.2; Met 1-Ser 364). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
SIRPG / SIRP gamma / CD172g抗体 Background
Signal-regulatory protein gamma, also known as SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-beta-2, CD172g and SIRPG, is a single-pass type I membrane protein. SIRPG / CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. It is expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. SIRPG / CD172g contains twoIg-like C1-type (immunoglobulin-like) domains and oneIg-like V-type (immunoglobulin-like) domain. It is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG / CD172g is primarily expressed in the medulla on mature T lymphocytes that have undergone thymic selection. SIRPG / CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, it mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
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