SIRT1抗体

SIRT1抗体产品信息

免疫原 :
Recombinant Human SIRT1 protein (Catalog#11748-H07E)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
3H10A10
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SIRT1 (rh SIRT1; Catalog#11748-H07E; NP_036370.2; Met 193-Ser 747). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
SIRT1抗体 Background
NAD-dependent deacetylase sirtuin-1, also known as SIR2-like protein 1, SIRT1 and SIR2L1, is a nucleus protein which belongs to thesirtuin family. SIRT1 / SIR2L1 is widely expressed and contains onedeacetylase sirtuin-type domain. Mammalian SIRT1 is an NAD-dependent deacetylase with critical roles in the maintenance of homeostasis and cell survival. Elevated levels of SIRT1 protein are evident in cancer in which SIRT1 can function as a cancer-specific survival factor. SIRT1 / SIR2L1 regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. It deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. SIRT1 / SIR2L1 deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. It is involved in HES1- and HEY2-mediated transcriptional repression. It inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. SIRT1 / SIR2L1 may serve as a sensor of the cytosolic ratio of NAD+/NADH, which is essential in skeletal muscle cell differentiation. In case of HIV-1 infection, it interacts with and deacetylates the viral Tat protein.
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