E-Selectin / CD62e / SELE抗体

E-Selectin / CD62e / SELE抗体产品信息

免疫原 :
Recombinant Rat E-Selectin / CD62e / SELE protein (Catalog#80033-R08H)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
04
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat E-Selectin / CD62e / SELE (rR E-Selectin / CD62e / SELE; Catalog#80033-R08H; P98105-1; Met 1-Pro 494). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
E-Selectin / CD62e / SELE抗体 Background
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed at relatively high density on the surface of cultured endothelial cells that have been activated by proinflammatory cytokines, such as IL-1β, TNF-α, or bacterial endotoxin. E-Selectin/CD62e exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-Selectin/CD62e recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-Selectin/CD62e supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. In addition, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis.
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