Peroxiredoxin 6 / PRDX6抗体

Peroxiredoxin 6 / PRDX6抗体产品信息

免疫原 :
Recombinant Human Peroxiredoxin 6 / PRDX6 protein (Catalog#11257-H07E)
Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
03
抗体宿主 :
Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Peroxiredoxin 6 / PRDX6 (rh Peroxiredoxin 6 / PRDX6; Catalog#11257-H07E; P30041; Met 1-Pro 224). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Peroxiredoxin 6 / PRDX6抗体Background
Peroxiredoxin-6, also known as 1-Cys peroxiredoxin, Acidic calcium-independent phospholipase A2, Antioxidant protein 2, Liver 2D page spot 40, Non-selenium glutathione peroxidase, PRDX6 and AOP2, is a cytoplasm protein which belongs to theahpC / TSA family and Rehydrin subfamily. Peroxiredoxin-6 / PRDX6 contains onethioredoxin domain. Peroxiredoxin-6 / PRDX6 is involved in redox regulation of the cell. Peroxiredoxin-6 / PRDX6 can reduce H2O2and short chain organic, fatty acid, and phospholipid hydroperoxides. Peroxiredoxin-6 / PRDX6 may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. The Peroxiredoxins / Prx are a family of 25 kDa peroxidases that can reduce H2O2 using an electron from thioredoxin (Trx) or other substances. The mammalian Peroxiredoxins / Prx family is divided into six groups (PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, PRDX6) on the basis of homology of amino acid sequences. They are located in the cytosol and play a role in the cell signaling system. All six mammalian peroxiredoxins are expressed in the lung. Peroxiredoxins / Prx is overexpressed in breast cancer tissues to a great extent suggesting that Peroxiredoxins / Prx has a proliferative effect and may be related to cancer development or progression.
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