CTSZ / CTSX / Cathepsin Z抗体

CTSZ / CTSX / Cathepsin Z抗体产品信息

免疫原 :
Recombinant Mouse CTSZ / CTSX / Cathepsin Z protein (Catalog#50089-M08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
009
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CTSZ / CTSX / Cathepsin Z (rM CTSZ / CTSX / Cathepsin Z; Catalog#50089-M08H; NP_071720.1; Met 1-Val 306).
CTSZ / CTSX / Cathepsin Z抗体Background
Cathepsin Z, also known as cathepsin X or CATX, belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic 'mini loop'.Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus, and in contrast to cathepsin B, it does not act as an endopeptidase. It is restricted to the cells of theimmune system, predominantly monocytes, macrophages and dendritic cells. Furthermore, higher levels of cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa, especially after infection by Helicobacter pylorin.
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