LDLR / LDL Receptor抗体

LDLR / LDL Receptor抗体产品信息

免疫原 :
Recombinant human LDLR protein ( Catalog#10231-H08H )
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
202
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human LDLR / LDL Receptor ( rh LDLR ; Catalog#10231-H08H ; NP_000518.1 ; Met 1 - Arg 788 ).
LDLR / LDL Receptor抗体背景综述
Low-density lipoprotein (LDL) is a type of lipoprotein that transports cholesterol and triglycerides from the liver to peripheral tissues, and enables fats and cholesterol to move within the water-based solution of the blood stream. The Low-Density Lipoprotein Receptor (LDLR) is the prototype member of the LDLR family of scavenger receptors which is involved in receptor-mediated endocytosis of specific ligands. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. LDLR recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles, as well as the apoE protein found in chylomicron remnants and VLDL remnants (IDL). After taken into the cell ending up in lysosomes, LDL is degraded and the cholesterol is made available for repression of microsomal enzyme HMG CoA reductase, the rate-limiting step in cholesterol synthesis. As a mosaic protein, the extracellular region of LDLR consists of seven N-terminal complement-like cysteinerich repeats followed by three EGF like repeats with a β-propeller YWTD containing motif, and a membrane proximal Ser/Thr rich region. Furthermore, it is reported that in case of HIV-1 infection, LDLR functions as a receptor for extracellular Tat (HIV-1 transactivator) into neurons, mediating its internalization in uninfected cells. Mutations in LDLR gene cause the autosomal dominant disorder, familial hypercholesterolemia.
LDLR / LDL Receptor抗体相关产品如下：
hz-5711R CCDC106卷曲螺旋结构域蛋白106抗体
hz-4207R CHMP1A染色质修饰蛋白1A抗体
hz-4516R CPN10叶绿体伴侣蛋白抗体（苹果）
hz-7783R CDC20B细胞分裂周期蛋白20B抗体
hz-7755R Cell division control protein septin D1细胞周期调控蛋白D1抗体
hz-7784R ccnb1ip1周期蛋白B1结合蛋白1抗体
hz-8614R Cdc14A细胞周期调控因子14A抗体
hz-9403R C7orf12第七号染色体开放阅读框12抗体
hz-8244R CA XI碳酸酐酶11抗体
hz-8245R Alpha caseinα酪蛋白抗体
hz-6905R CDCREL细胞周期调控相关蛋白1
hz-6326R ICAM1细胞间粘附分子1抗体
hz-6323R CD105CD105抗体
hz-11453R CNTN5轴突蛋白5抗体
hz-11454R COUP-TF1转录因子COUP1抗体
hz-11460R CELSR3表皮生长因子样蛋白1抗体
hz-4896R CD66a癌胚抗原相关细胞粘附分子1抗体
hz-13797R C19orf7519号染色体开放阅读框75抗体
hz-11441R Cryptochrome 1隐花色素蛋白1抗体
hz-11447R CRY2隐花色素蛋白2抗体
hz-11981R CACNA2钙通道L型α2多肽抗体
hz-11982R CACNB3L型电压依赖型钙通道β3(L-type Ca++ CPβ3)抗体
hz-11983R CACNB4L型电压依赖型钙通道β4抗体
hz-11984R CACNA1G + CACNA1H电压依赖性钙通道CACNA1G+CACNA1H抗体
hz-11986R CABP1钙结合蛋白1抗体
hz-11987R CAPON神经型一氧化氮合成酶结合蛋白抗体
hz-11998R CHRM4毒蕈碱型乙酰胆碱受体M4抗体
hz-0771R CaMK2 alpha钙/钙调素依赖蛋白激酶2α抗体
hz-11975R CACYBP周期蛋白结合蛋白抗体
hz-7786R CDCA2细胞分裂周期蛋白2抗体
hz-7785R CDC45L细胞分裂周期调控蛋白45抗体
hz-7780R CAPH染色体相关蛋白H抗体
hz-7788R CEP76中心体蛋白质76抗体
hz-7787R CEP152中心体蛋白152抗体
hz-12425R Casein kinase 1 gamma 2酪蛋白激酶1γ2/casein kinase Iγ1抗体
hz-8018R CLPTM1唇裂和腭裂相关跨膜蛋白1抗体
hz-8024R CKLFH8趋化素样因子超家族成员8抗体
hz-8020R CKLFH1趋化素样因子超家族成员1抗体
hz-8017R CLN6神经细胞蜡样质脂褐质沉积病蛋白CLN6抗体
hz-12005R CEP104甘氨酸结合蛋白抗体