DR6 / TNFRSF21抗体

DR6 / TNFRSF21抗体产品信息

免疫原 :
Recombinant human DR6 protein ( Catalog#10175-H08H )
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
001
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human TNFRSF21 ( rh TNFRSF21 ; Catalog#10175-H08H ; Met 1 - Leu 350 ; NP_055267.1)
DR6 / TNFRSF21抗体Background
Human death receptor-6 ( DR6 ) is identified as a member of TNF receptor superfamily. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is expressed in most human tissues and the highest levels were detected in heart, brain, placenta, pancreas, thymus, lymph node and several non-lymphoid cancer cell lines. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. In addition, DR6 is uniquely cleaved from the cell surface of tumor cell lines by the membrane-associated matrix metalloproteinase (MMP)-14, which is associated with tumor malignancy.
DR6 / TNFRSF21抗体相关产品如下：
hz-13778R 5HT2C Receptor5-羟色胺受体2C抗体
hz-13779R 5HT5B Receptor5-羟色胺受体5B抗体
hz-8069R SRRM4丝氨酸/精氨酸相关核基质蛋白4抗体
hz-8068R SRRM3丝氨酸/精氨酸相关核基质蛋白3抗体
hz-7909R phospho-CK II beta (Ser209)磷酸化丝氨酸/苏氨酸蛋白激酶II β(casein kinase IIβ)抗体
hz-8060R MOP5单核细胞蛋白5抗体
hz-9002R SAMD9SAMD9蛋白抗体
hz-9001R SARM1SARM1蛋白抗体
hz-9392R p150 CAF1染色质组装因子1P155抗体
hz-11424R Sauvagine蛙皮降压肽抗体
hz-7927R SIPA1L2信号诱导增殖相关蛋白1样蛋白2抗体
hz-7922R SKARDNA聚合酶δ相互作用蛋白3抗体
hz-7923R SRPK2丝氨酸/苏氨酸蛋白激酶SRPK2抗体
hz-6907R Septin 8细胞分化蛋白SEPT8抗体
hz-7773R SPECC1L细胞质和纺锤体机化蛋白A抗体
hz-7769R SEPT1细胞分化蛋白SEP1抗体
hz-7770R SEPT10细胞分化蛋白SEPT10抗体
hz-7771R SEPT12细胞分化蛋白SEPT12抗体
hz-11260R SNIP1Smad核相互作用蛋白1抗体
hz-11261R Syntaxin 6突触融合蛋白6抗体
hz-11216R Sprouty1软脂酰化磷蛋白Sprouty1抗体
hz-11221R SH3TC2脱髓鞘相关蛋白SH3TC2N抗体
hz-11238R SHANK2富含脯氨酸突触相关蛋白SHANK2抗体
hz-9581R SHARPIN线性泛素链相关蛋白SHARPIN抗体
hz-9003R SAMD7SAMD7蛋白抗体
hz-9004R SAMD3SAMD3蛋白抗体
hz-11065R Syntrophin gamma 2肌蛋白结合蛋白γ2抗体
hz-11207R SOX22核转录因子SOX22抗体
hz-11208R SOX4核转录因子SOX4抗体
hz-11209R SUFU/Suppressor of Fused抑制Hh信号通路蛋白SUFU抗体
hz-1371R SNAILSnail蛋白抗体
hz-9478R SARP1分泌细胞凋亡相关蛋白1抗体
hz-9479R SMARCD3肌动蛋白依赖染色质调控因子SMARCD3蛋白抗体
hz-7577R SLC25A6线粒体载体腺嘌呤核苷酸转运蛋白6抗体
hz-7578R SODDBcl2结合抗凋亡蛋白4抗体
hz-9720R C10orf27第10号染色体开放阅读框27抗体
hz-1056R 5-HTR2A5-羟色胺受体2A抗体
hz-0526R 5 lipoxygenase5-脂氧合酶抗体
hz-8549R SH2B1SH2B蛋白抗体