REG3G / PAP1B抗体

REG3G / PAP1B抗体产品信息

免疫原 :
Recombinant human REG3G protein ( Catalog#11641-H08H )
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
002
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human REG3G ( rh REG3G ; Catalog#11641-H08H ; NP_001008388.1 ; Met 1 - Asp 175 ).
REG3G / PAP1B抗体背景综述
Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family consisting of four subtypes (types I, II, III, IV) and are involved in cancers and neurodegenerative diseases. Regenerating islet-derived 3 gamma (REG3G), also known as pancreatitis-associated protein 1B ( PAP1B), is a member of the secreted Reg superfamily and contains one typical C-type lectin domain. REG III was expressed predominantly in pancreas, as well as in testis. REG3G might be a stress protein involved in the control of bacterial proliferation. It was indicated that REG3G specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer, and serves as one of several antimicrobial peptides produced by paneth cells via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs).
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