Anti Bovine PI3 Kinase (p85 al

Antisense Oligonucleotides Targeting RI Subunit of Protein Kinase A: In Vitro and In Vivo Anti-Tumor Activity and Pharmacokinetics

cAMP-dependent protein kinase (PKA) is involved in various cellular functions such as cell proliferation, gene induction, and metabolism (1 ,2 ) and its regulatory subunits have been suggested as a drug target for cancer and other diseases

PI3K―Akt信号通路

PI3K ― Akt 信号通路PI3K是一个复杂的大家族，根据其结构可分为3类：I型、Ⅱ型、Ⅲ型。 I型PI3K又分为IA和IB两个亚型，他们分别从酪氨酸激酶连接受体和G蛋白连接受体传递信号，其作用是催化磷脂酰肌醇(P1)在D3位的磷酸化，把底物PIP2转化为PIP3。IA型P13K是由催化亚单位Pll0和调节亚单位P85所组成的二聚体蛋白，具有类脂激酶和蛋白激酶的双重活性。在正常细胞中，P13K的活性是受许多机制严格控制的。一般认为，在静息细胞中，无活性的P85―P1lo复合物普遍

Measurement of Phosphoinositide 3-Kinase Activity

class IA PI 3-kinase is a heterodimer consisting of the 85 kDa regulatory subunit (responsible for protein-protein interactions either via protein tyrosine phosphate-binding SH2 domains or SH3 domains and/or proline rich regions) and a catalytic 110 kDa