DLL4 / Delta-4抗体

DLL4 / Delta-4抗体产品信息

免疫原 :
Recombinant mouse DLL4 protein ( Catalog#50640-M08H )
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
006
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant mouse DLL4 ( rM DLL4 ; Catalog#50640-M08H ; NP_062327.2 ; Met 1 - Pro 525 ).
DLL4 / Delta-4抗体 Background
Mouse Delta-like protein 4 ( DLL4 ) is a type I membrane-bound Notch ligand characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding, and is suggested to play a key role in vascular development and tumor angiogenesis. The Notch pathway is an evolutionary conserved intercellular signaling pathway involved in numerous biological processes including cell fate determination, cellular differentiation, proliferation, survival, and apoptosis. In mammalian cells, five Notch ligands (Jagged1, 2, DLL1, 3, 4) and four Notch receptors (Notch1-4) have been identified, and ligand-receptor interactions results in proteolysis and translocation of the Notch intracellular domain. As a ligand for Notch1 and Notch4, DLL4 is sel ectively expressed in the developing endothelium and in some tumor endothelium, and is induced by vascular endothelial growth factor (VEGF)-A and hypoxia. In recent studies, it has been revealed that this DLL4 inhibition may paradoxically lead to increased angiogenesis but poor tumor growth because of the non-functional. neovascularization, and constitutive expression of DLL4 may leads to a lethal lymphoproliferative disease. Accordingly, this may provide a new therapeutic approach for certain carcinomas.
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