IL11RA / IL11Rα抗体

IL11RA / IL11Rα抗体产品信息

免疫原 :
Recombinant mouse IL11RA protein ( Catalog #50075-M08H )
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
025
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant mouse IL11RA ( rM IL11RA ; Catalog #50075-M08H ; NP_001156873.1 ; Met 1 - Gln 367 )
IL11RA / IL11Rα抗体 Background
Mouse interleukin-11 receptor alpha chain, also known as IL-11R-alpha, and IL11RA, is a single-pass type I membrane protein. It belongs to the type I cytokine receptor family and type 3 subfamily and contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. Interleukin 11 receptor is a heterodimer composed of an interleukin 11 receptor alpha subunit and an incompletely characterized beta subunit. IL11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. IL11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and differentiation of skeletogenic progenitor or other mesenchymal cells.
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