CD34抗体

CD34抗体产品信息

免疫原 :
Recombinant Human CD34 protein (Catalog#10103-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
009
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD34 (rh CD34; Catalog#10103-H08H; NP_001020280.1; Met 1-Thr 290).
CD34抗体 Background
CD34 molecule is a member of a family of single-pass transmembrane sialomucin proteins, and is selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. Although used clinically in hematopoietic stem cell transplantation for more than 15 years, little is known about the exact function of CD34. It may act as an adhesion molecule in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells, and is also required for T cells to enter lymph nodes via interaction with L-selectin. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis.
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