Macrophage F4/80 Gen 抗体

Macrophage F4/80 Gen 抗体
抗原
Macrophage F4/80 Gen
适用
其他选择 小鼠
宿主
其他选择 大鼠
克隆类型 (克隆位点)
单克隆 (CI:A3-1)
标记
其他选择 PE
Macrophage F4/80 Gen 抗体应用范围
其他选择 流式细胞分析技术（FACS）, 免疫萤光（IF）
Pubmed 13个引用可参考
规格 100 tests
发货至 中国 (更改)
产品细节
免疫原 Thioglycollate stimulated peritoneal cavity macrophages from C57/BL mice. Remarks: Spleen cells from immunised HOB2 rats were fused with cells of the mouse NS-1 mouse myeloma cell line.
克隆位点 CI:A3-1
亚型 IgG2b
特异性 This antibody recognises the F4/80 antigen. Clone CI:A3-1 has been reported to modulate cytokine levels released in response to Listeria monocytogenes (5). We recommende the use of Cat.-No BM4008LE for this purpose.
交叉反应 （详细） Species reactivity (tested):Mouse.
纯化方法 Affinity Chromatography on Protein A
目标详细情况
别名 Macrophage F4/80 Antigen
背景 Murine F4/80 antigen is a 160 kD cell surface glycoprotein that is a member of the EGF-TM7 family of proteins which shares 68 % overall amino acid identity with Human EGF module-containing mucin-like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.Synonyms: Cell surface glycoprotein EMR1, EMR1 hormone receptor, Emr1, Gpf480
基因ID 13733
NCBI登录号 NP_034260
UniProt Q61549
使用细节
Macrophage F4/80 Gen 抗体应用备注 Flow Cytometry: use 10 μL of neat antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
贮存及处理
溶解方式 Restore with 1 mL distilled water.
缓冲液 PBS, pH 7.4, 0.09 % Sodium Azide, 1 % BSA, 5 % Sucrose
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 This product is photosensitive and should be protected from light
储存条件 4 °C
储存方法 Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
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