Osteonectin / SPARC抗体

Osteonectin / SPARC抗体产品信息

免疫原 :
Recombinant Mouse Osteonectin / SPARC protein (Catalog#50494-M08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
001
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Osteonectin / SPARC (rM Osteonectin / SPARC; Catalog#50494-M08H; NP_033268.1; Met1-Ile302).
Osteonectin / SPARC抗体Background
Secreted protein acidic and rich in cysteine (SPARC), also known as Osteonectin (ON), is a member of the SPARC family. SPARC contains a EF-hand domain, a follistatin-like domain and a Kazal-like domain. It is expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair. SPARC has two calcium binding sites; an acidic domain that binds 5 to 8 Ca2+with a low affinity and an EF-hand loop that binds a Ca2+ion with a high affinity. SPARC appears to regulate cell growth through interactions with the extracellular matrix and cytokines.It binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. The activity of SPARC is context- and cell-type-dependent, which is highlighted by the fact that SPARC has shown seemingly contradictory effects on tumor progression in both clinical correlative studies and in animal models. SPARC enhances the Wnt/beta-catenin signaling pathway and regulates the expression and posttranslational modification of collagen. SPARC might drive preadipocytes away from the status of growth arrest and therefore prevent terminal differentiation. SPARC could also decrease WAT deposition through its negative effects on angiogenesis.
Osteonectin / SPARC抗体相关产品如下：
hz-1297R CD28CD28抗体
hz-15053R C1orf195 1号染色体开放阅读框195抗体
hz-2419R KIR2DL1NK细胞抑制性受体2DL1抗体
hz-15182R C3orf673号染色体开放阅读框67抗体
hz-10031R CSN3κ-酪蛋白抗体
hz-2466R Siglec 7唾液酸结合性免疫球蛋白样凝集素7抗体
hz-9895R CappuccinoCappuccino蛋白抗体
hz-9896R Cyclooxygenase 3前列腺素过氧化物合成酶3抗体
hz-9905R CFHL1补体因子H相关蛋白1抗体
hz-9907R CPN2羧肽酶CPN2抗体
hz-9921R CAMK2D钙/钙调素依赖蛋白激酶2D(CaMKIIδ)
hz-0372R NT5C2胞浆-5′-核苷酸酶-Ⅱ抗体
hz-1035R CD86CD86抗体
hz-0542R CDK1周期素依赖性激酶1抗体
hz-0757R CDK2周期素依赖性激酶2抗体
hz-0633R CDK4周期素依赖性激酶4抗体
hz-0559R CDK5周期素依赖性激酶5抗体
hz-15055R C1orf2001号染色体开放阅读框200抗体
hz-15242R c6orf2236号染色体开放阅读框223抗体
hz-2222R cellulase纤维素酶抗体
hz-8541R CLEC 4EC型凝集素4家族E抗体
hz-0236R ChRM2毒蕈碱型乙酰胆碱受体抗体
hz-0441R ChRM2毒蕈碱型乙酰胆碱受体M2抗体
hz-0544R CIDEB促进凋亡基因抗体
hz-0670R C-jun原癌基因蛋白/活化蛋白1抗体
hz-6796R CIDEC细胞死亡活化蛋白抗体
hz-1028R Cytokeratin 19细胞角蛋白19抗体
hz-1005R CK2细胞角蛋白2抗体
hz-1006R CK4细胞角蛋白4抗体
hz-3879R Cytochrome b245 Light Chain细胞色素b245轻链抗体
hz-15205R C5ORF445号染色体开放阅读框44抗体
hz-7685R Corin心脏特异性丝氨酸蛋白酶抗体
hz-7560R CPLA2胞浆型磷脂酶A2抗体
hz-7064R CCAR1细胞周期及凋亡调节蛋白1抗体
hz-0805R CD56神经细胞粘附分子1抗体
hz-1241R Claudin 5紧密连接蛋白5抗体
hz-2034R CRIM1富含半胱氨酸运动神经元蛋白1抗体
hz-1660R CK5+6细胞角蛋白5+6抗体
hz-0842R c-Myc tagc-Myc tag标签抗体
hz-0848R CSP环子孢子蛋白(约氏疟原虫)抗体
hz-15172R C3orf30 3号染色体开放阅读框30抗体
hz-0811R CX3CL1CX3CL1抗体
hz-0488R CXorf36脱羧酶蛋白体36抗体
hz-15183R C3orf783号染色体开放阅读框78抗体
hz-0324R C5a anaphylatoxin过敏毒素C5a/补体C5a抗体
hz-0091R CA125卵巢癌抗原抗体
hz-1685R CTNNAL1粘附分子相关蛋白a1抗体
hz-15127R C21orf6921号染色体开放阅读框69抗体