Carbonic Anhydrase IV / CA4抗体

Carbonic Anhydrase IV / CA4抗体产品信息

免疫原 :
Recombinant Human Carbonic Anhydrase IV / CA4 protein (Catalog#10472-H08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
039
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Human Carbonic Anhydrase IV / CA4 (rh Carbonic Anhydrase IV / CA4; Catalog#10472-H08H; NP_000708.1; Met1-Lys283).
Carbonic Anhydrase IV / CA4抗体 Background
Carbonic anhydrase 4, also known as Carbonic anhydrase IV, CAIV, and CA4, is a member of the alpha-carbonic anhydrase family. CA4 is a membrane-associated enzyme anchored to plasma membrane surfaces by a phosphatidylinositol glycan linkage. It is expressed on the luminal surfaces of pulmonary capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport. Similar to human CA4, the C-terminus of murine CA4 is surrounded by a substantial electropositive surface potential that may stabilize the interaction with the phospholipid membrane. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. The genomic data suggests that there are thirteen enzymatically active members of the mammalian CA isozyme family. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization.
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