vWF抗体

vWF抗体产品信息免疫原 : CHO cell-derived rhvWF ( Catalog#10973-H08C )

抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, CHO cell-derived, recombinant human von Willebrand factor (rhvWF; Catalog#10973-H08C; aa 1- 2813; NP_000543.2). Total IgG was purified by Protein A affinity chromatography.
vWF抗体背景综述
Von Willebrand factor (vWF) is a blood glycoprotein which is involved in a large number of diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome. Its primary function is binding to other proteins, particularly Factor VIII and it is important in platelet adhesion to wound sites. vWF appears to play a major role in blood coagulation. Its deficiency or dysfunction leads to a bleeding tendency, which is most apparent in tissues having high blood flow shear in narrow vessels. It appears that vWF uncoils under these circumstances, decelerating passing platelets. Hereditary or acquired defects of vWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing menorrhagia, and gastrointestinal bleeding.
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