细胞增殖标志物(Proliferation Marker)
Ki67与PCNA一样,为细胞增殖的一种标记,在细胞凋亡中S、G2 、M期均有表达,G0期缺如。
Ki-67增殖指数高低与许多肿瘤的分化程度、浸润、转移以及预后密切相关,因此被广泛作为各种恶性肿瘤的必检项目之一。
Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.
mol wt:358kDa
Other Aliases: Antigen identified by monoclonal antibody Ki 67; Antigen KI67; KIA; Ki-67; MKI67; Proliferation related Ki 67 antigenxy-0427xy P311 protein增生性瘢痕相关蛋白(抗原)
xy-0769xy PARP(poly ADP-ribose polymerase)多腺苷二磷酸多聚酶抗原
xy-0270xy Visfatin-1 (PBEF1)(NT) Human内脂素/内脏脂肪素(人:N端多肽)、内脏脂肪素、 又称:前B细胞克隆增强因子、内肥素、腹脂素
xy-0272xy Visfatin-1 (PBEF1)(NT) 内脂素/内脏脂肪素
xy-0273xy PBEF (CT)内脂素/B细胞克隆增强因子
xy-0731xy PEDF (pigment epithelium-derived factor)色素上皮源性因子(多肽抗原)
xy-0739xy PAP2c (Phosphatidic acid phosphatase 2c)磷脂酸磷酸酶2C(抗原)
xy-0689xy PEPT1 (Peptide-transporters 1)肠道肽转运蛋白(小肽转运蛋白)多肽
xy-0748xy PTEN/MMAC1一种肿瘤抑制基因抗原
xy-0420xy PIBF(progesterone induced blocking factor)孕激素诱导阻断因子(抗原)
xy-0665xy PIWIL1(piwi-like 1)piwi 样1蛋白(抗原)
xy-0530xy PPAR Gamma (peroxisome proliferator-activated receptor-gamma)过氧化酶活化增生受体γ(抗原)
xy-0490xy PP2Ac蛋白磷酸酶4(抗原)
xy-0378xy Runx3一种新发现的抑癌基因(抗原)
xy-0278xy RRAD (Ras-related associated with diabetes )RRAD(多肽抗原)
xy-0783xy SDF-1/CXCL12 (stromal cell derived factor-1)基质细胞衍生因子-1(抗原)
xy-0211xy shank1(SH3 and multiple anleyrin repead domins protein 1)shank1多肽抗原
xy-0444xy slc22A17 (solute carrier famili 22)溶质转运蛋白家族22成员17(多肽抗原)
xy-0496xy SLC24A5 (solute carrier family 24, member 5)可溶性载质转运蛋白SLC24A5(抗原)
xy-0473xy solute carrier family 1溶质携带物家族-1(抗原)
xy-0478xy SLC6A4 (solute carrier family 6)钾依赖钠钙交换蛋白6(抗原)
xy-0615xy Survivin细胞凋亡抑制因子的一种(抗原)
xy-0635xy SSA/RO (ribonucleoprotein complex,RNP)核糖核蛋白抗原RO/SSA(抗原)
xy-0276xy SSB/La干燥症SSB/La蛋白
Ki-67 Antigen抗体