MMP-9抗体

MMP-9抗体产品信息免疫原 : Recombinant human MMP-9 protein ( Catalog #10327-H08H )

抗体类型: Biotin conjugated Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )

克隆号 : 43
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS with 3% BSA
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human matrix metallopeptidase 9 ( rh MMP-9 ; Catalog#10327-H08H ; Met 1 - Asp 707 ; NP_004985.2 ) and then biotinylated.
MMP-9抗体背景综述
Matrix metalloproteinase-9, also known as 92 kDa type IV collagenase, MMP-9 and CLG4B is a secreted protein which belongs to the peptidase M10A family. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. MMP-9 contains three fibronectin type-II domains and four hemopexin-like domains. It is secreted from neutrophils, macrophages, and a number of transformed cells. It is the most complex family member in terms of domain structure and regulation of its activity. MMP-9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.
MMP-9 may play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. MMP-9 could play a role in bone osteoclastic resorption. It cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. MMP-9 also degrades fibronectin but not laminin or Pz-peptide. MMP-9 and MMP-13 catalyze the degradation of extracellular matrix (ECM) components in the growth plate and at the same time cleave and release biologically active molecules stored in the ECM, such as VEGFA. In mice, ablation of MMP-9, MMP-13, or both MMP-9 and MMP-13 causes severe distortion of the metaphyseal growth plate. MMP-9 has also been implicated in numerous somatic illnesses, including cardiovascular disorders and cancer. MMP-9 has been shown to be increasingly important in several aspects of central nervous system activity. Defects in MMP-9 may be a cause of susceptibility to intervertebral disc disease (IDD), also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain.
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