H1N1 HA Antibody

Influenza (flu) is a respiratory infection in mammals and birds. This virus is divided into three main types (A, B and C). Influenza A is found in a wide variety of bird and mammal species. Influenza B is largely confined to humans and is an important cause of morbidity. Influenza C infects humans, dogs and pigs, sometimes causing both severe illness and local epidemics. Influenza A is further divided into subtypes based on differences in the membrane proteins hemagglutinin (HA) and neuraminidase (NA). The notation HhNn is used to refer to the subtype comprising the hth discovered HA protein and the nth discovered NA protein. The HA is a trimer with a receptor binding pocket on the globular head of each monomer. Subtypes are further divided into strains. Each genetically distinct virus isolate is usually considered to be a separate strain.
The H1N1 viral strain ( A/California/04/2009 ) implicated in the 2009 flu pandemic among humans is often called "swine flu" because initial testing showed many of the genes in the virus were similar to influenza viruses normally occurring in North American swine. Two children in southern California were infected with H1N1 swine flu. The isolates are similar and have an unusual constellation of genes. The lack of contact between the two children, as well as a lack of contact with swine, suggests the virus is spreading human to human. The presence of swine H1N1 in humans raises concerns of recombination with H1N1 seasonal flu. Moreover, the 1918 pandemic strain was a recombinant between human H1N1 and swine H1N1. The likely ability of this swine H1N1 to transmit efficiently in humans is cause for concern. The HA, NA, and MP sequences of A/California/04/2009 have been placed on deposit at GISAID.
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