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- xy10302-RP01
- 2025年07月12日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
FXI / F11 / Factor XI抗体
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human Factor XI ( rh Factor XI ; Catalog#10302-H08H ; NP_000119.1 ; Met 1- Val 625 ). Total IgG was purified by Protein A affinity chromatography.
FXI / F11 / Factor XI Antibody Background
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa and then is processed into a disulfide-bond linked homodimer. Factor XI is is converted to an active protease, factor XIa, by factor XIIa ( or factor XII) in the presence of high molecular weight kininogen (HMWK) and a polyanionic surface. After the activation reaction, Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX, while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. The vast majority of the FXI deficiencies have been found in the Ashkenazi Jewish population.
FXI / F11 / Factor XI抗体相关产品如下：xy-2210xy phospho-p38 ERK/MAPK14 (pThr180/pTyr182) peptide磷酸化丝裂原活化蛋白激酶p38抗原
xy-1689xy MKK3(MAP Kinase Kinase 3)丝裂原活化蛋白激酶MKK3/6抗原
xy-2090xy P53(wt-p53)肿瘤抑制基因抗原（野生型P53）
xy-0913xy Mtp53(Mutant type p53)突变型P53抗原
xy-0942xy WIG-1(wtp53-induced gene 1)野生型p53诱导基因1抗原
xy-1346xy P73 proteinP73肿瘤抑制基因抗原
xy-1426xy p70 S6 Kinase/P70 Beta1p70S6Kb抗原
xy-0588xy PALB2(partner and locaizer of BRCA2)乳腺癌易感基因相关蛋白2
xy-1478xy PAFR/PTAFR血小板活化因子受体抗原
xy-2270xy Phospho-PAK4 (Ser99) peptide磷酸化p21激活激酶4多肽抗原
xy-0655xy PAK7/PAK5/MBT激活激酶PAK7/PAK5抗原
xy-0828xy PAR-1 (Protease-activated receptors-1)蛋白酶激活受体-1抗原
xy-1178xy PAR-2 (Protease-activated receptors-2)蛋白酶激活受体-2抗原
xy-1196xy PAR4 (protease-activated receptor 4)蛋白酶活化受体4/前列腺细胞凋亡反应蛋白4抗原
xy-2138xy PARP(poly ADP-ribose polymerase)N-Terminus多腺苷二磷酸多聚酶抗原(N端)
xy-1201xy PAX8(Paired box gene 8)配对盒基因8抗原
xy-1102xy PAX9(Paired box gene 9)配对盒基因9抗原
xy-1159xy P-cadherin(placental)P-钙粘附分子抗原
xy-1617xy LI-cadherin(liver-intestine cadherin)肝肠钙粘连蛋白抗原
xy-1608xy PDCD4(programmed cell death 4)凋亡相关蛋白4抗原
xy-1333xy TFAR19(TF-1 cell apoptsis-related gene 19)凋亡相关蛋白TFAR19抗原
xy-2215xy PCNA(phosphos Dyr211)peptide磷酸化增殖细胞核多肽抗原
xy-1345xy PCX/PODXL(Podocalyxin)足细胞特异蛋白抗原
xy-1316xy PDGF-BB peptide血小板源性生长因子-BB抗原
xy-0923xy Pdx1(pancreatic and duodenal homeobox 1)胰十二指肠同源异型盒基因抗原
xy-2219xy pectinesterase inhibitor 18 peptide果胶酶抗原
xy-1084xy PEG10(Paternally expressed gene 10)肝癌高表达基因抗原
xy-2106xy PENK/Enkephalin A(Preproencephalin A)脑啡肽
xy-0584xy PEPT2 (Peptide-transporters 2)肠道肽转运蛋白2/小肽转运蛋白2抗原
xy-2469xy PERK(PRKR-like endoplasmic reticulum kinase)蛋白激酶R样内质网激酶抗原
xy-0796xy FSCN1 (Fascin 1 protein; fascin homolog 1, actin-bundling protein)纤维束蛋白同源物1/肌动蛋白集束蛋白/圆线虫紫癜 抗原
xy-1551xy Pepsinogen C peptide胃蛋白酶原C蛋白抗原
xy-1832xy PGC-1 Alpha(peroxisome proliferator-activated receptor- Gamma coactivator 1 Alpha)过氧化物酶体增殖物激活受体γ辅激活子1α抗原
xy-0823xy PGRN (progranulin)颗粒蛋白前体抗原
xy-1449xy PHB(Prohibitin)抑制素/肿瘤抑制因子抗原
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文献和实验Molecular Analysis in Factor XI Deficiency
Factor XI (FXI) is the zymogen precursor of an active serine protease that participates in the contact phase of coagulation. Synthesized in the liver, it circulates in the plasma in a noncovalent complex with high molecular weight kininogen
人转录因子E2F1 ( E2F1 )ELISA 试剂盒 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 E2F1 单抗包被于酶标板上，标准品和样品中的 E2F1与单抗结合，加入生物素化的抗人 E2F1 ，形成免疫复合物连接在板上，辣根过氧化物酶标记的 Streptavidin 与生物素结合，加入底物工作液显蓝色，最后加终止液硫酸，在 450nm 处测 OD 值，E2F1 浓度与 OD 值成正比
X性联无丙种球蛋白血症(X-linked agammagl，bulinemia，XLA)是临床上首次确定的体液免疫缺陷病，由Brutor于1952年报道，故又称Bruton病。XLA作为常见的原发性免疫缺陷病之一，特点为血清中各类免疫球蛋白缺乏，或只能测得微量的抗体。外周血和淋巴组织中B细胞减少或完全缺乏，淋巴结中无生发中心和浆细胞。本病起病早，在出生数月后当患儿体内的母源性抗体水平下降时开始发病。临床表现为反复化脓性感染，患者细胞免疫功能不受影响(部分患者有T细胞数量减少)，主要缺陷
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