IFNGR1 / IFN-gamma-R1抗体

IFNGR1 / IFN-gamma-R1抗体产品信息免疫原 : Recombinant human CD119 protein ( Catalog#10338-H08H )

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 10
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human IFNGR1 / CD119 ( rh IFNGR1 ; Catalog#10338-H08H ; NP_000407.1 ; Met 1- Gly 245 ).
IFNGR1 / IFN-gamma-R1抗体背景综述
The protein IFN-γR1 (IFNGR1) is the ligand-binding chain (alpha) of the high-affinity interferon gamma receptor complex which is a heterodimer of IFN-γ R1 (IFN-γ Rα) and IFN-γ R2 (IFN-γ Rβ). IFN-γ R1 is necessary and sufficient for IFN-γ binding and receptor internalization, whereas IFN-γ R2 is required for IFN-γ signal transduction, but does not bind IFN-γ by itself. IFN-γ R1 is constitutively expressed in most cell types and soluble IFN-γ R1 has been detected in biological fluids. Human IFN-γ R1 cDNA encodes a 499 aa residue protein consisting of a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Upon binding to IFN-γ receptor via its C-terminus, the type II interferon IFN gamma triggers multiple intracellular signalling processes including prevention of viral replication, inhibition of cell growth, modulation of cell differentiation, and induction of growth arrest at mid-G1 in different mammary carcinoma cell lines. A genetic variation or deficiency in IFN-γR1 is associated with susceptibility to Helicobacter pylori infection or mycobacterial disease.
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