缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human TREM2 ( rh TREM2 ; Catalog#11084-H08H ; NP_061838.1 ; Met 1 - Ser 174 ). Total IgG was purified by Protein A affinity chromatography.
TREM2抗体背景综述
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary. TREM2抗体相关产品如下:xy-2699R OMPC大肠杆菌外膜孔道蛋白C抗体 xy-2693R Plexin B1神经丛蛋白B1抗体 xy-5560R phospho-PRKCZ(Thr410)磷酸化蛋白激酶C(T410)抗体 xy-5561R phospho-PRKD1(Ser738)磷酸化蛋白激酶C mu型抗体 xy-5563R phospho-PRKD1(Tyr463)磷酸化蛋白激酶C mu型抗体 xy-2690R PILR beta细胞表面受体PILRβ抗体 xy-7002R PAGE4前列腺癌相关蛋白4抗体 xy-7003R PMPCB线粒体导肽水解酶β抗体 xy-9408R PRR15富含脯氨酸蛋白15抗体 xy-10486R protein C light chain维生素K依赖的蛋白C轻链抗体 xy-10487R protein C Activation peptide xy-0686R PTEN一种肿瘤抑制基因抗体(C端) xy-1478R PAFR血小板活化因子受体抗体 xy-5422R PP1C gamma蛋白磷酸酶γ1抗体 xy-4181R p53R2核苷酸还原酶M2B抗体 xy-2384R PDE4A磷酸二酯酶4A抗体 xy-3643R PLASTIN3丝束蛋白T Plastin抗体 xy-3638R Plexin A2神经丛蛋白A2抗体 xy-3640R Plectin网蛋白抗体 xy-10171R PTOV1前列腺肿瘤高表达蛋白1抗体 xy-5596R phospho-P53(Thr55)磷酸化肿瘤抑制基因P53抗体 xy-4180R P2Y2嘌呤ATP受体抗体 xy-2210R phospho-p38 MAPK (Thr180 + Tyr182)磷酸化丝裂原活化蛋白激酶p38抗体 xy-2219R Pectinesterase inhibitor 18果胶酶抑制蛋白18抗体 xy-3614R PPAR alphaα型-过氧化酶活化增生受体抗体(PPAR α, PPAR-α) xy-2561R PSGD/HOXB13同源盒蛋白HOXB13抗体 xy-5537R Phospho-PDPK1(Ser393)磷酸化3磷酸肌醇依赖性蛋白激酶1抗体 xy-3716R Phospho-p63 (Ser160+Ser162)磷酸化P63肿瘤抑制基因抗体 xy-2270R Phospho-PAK4(Ser99)磷酸化p21激活激酶4抗体 xy-3717R Phospho-p73(Tyr99)磷酸化P73肿瘤抑制基因抗体 xy-3718R Phospho-p95 NBS1 (Ser343)磷酸化DNA修复蛋白NBS1抗体 xy-1573R PUMAp53正向细胞凋亡调控因子抗体 xy-4151R PLDL1磷脂酶C1样蛋白抗体 xy-6742R Prostate and colon associated protein前列腺癌和结肠癌相关蛋白 xy-0361R Protein G重组蛋白G抗体