IL18R1 / CD218a抗体

IL18R1 / CD218a抗体产品信息免疫原 : Recombinant human IL18R1 protein ( Catalog#11102-H08H )

抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human IL18R1 / CD218a ( rh IL18R1 ; Catalog#11102-H08H ; NP_003846.1 ; Met 1 - Arg 329 ). Total IgG was purified by Protein A affinity chromatography.
IL18R1 / CD218a抗体背景综述
The interleukin-18 receptor 1 ( IL18R1 ), also known as CDw218a ( cluster of differentiation w218a ), is a cytokine receptor that belongs to the immunoglobulin superfamily and interleukin 1 receptor family. IL18R1 is a single-pass type I membrane protein containing three Ig-ike C2-type domains within the ECD. It specifically binds interleukin 18 (IL-18) and is essential for IL18 mediated signal transduction, and it is reported that binding to the agonist leads to the activation of NF-kappa-B. IL-18R1 induces synthesis and release of IFN-gamma, IL8, IL4 and IL13, TNF-alpha and granulocyte/macrophage colony stimulating factor (GM-CSF). It modulates the function of many immunocompetent cells including macrophages, monocytes, lymphocytes and granulocytes. Another feature of IL-18 receptor is its ability to induce apoptosis of many cell types by inducing Fas ligand and receptor, as well as granzymes. High level of IL18R1 expression is detected in Hodgkin's disease cell lines.
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