SPP1 / OPN抗体

SPP1 / OPN抗体产品信息免疫原 : Recombinant human SPP1 protein ( Catalog#10352-H08H )

抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human SPP1 ( rh SPP1 ; Catalog#10352-H08H ; NP_001035147.1 ; Met 1 - Asn 314 ). Total IgG was purified by Protein A affinity chromatography.
SPP1 / OPN抗体背景综述
Osteopontin, also known as Secreted phosphoprotein 1, Bone sialoprotein 1, BSP-1, OPN, and SPP1, is a member of the osteopontin family and a SIBLING glycoprotein that was first identified in 1986 in osteoblasts. It is an extracellular structural protein and therefore an organic component of bone. Osteopontin is expressed in bone, although it is also expressed in other tissues. Osteopontin acts as a cytokine which is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. It is essential in the pathway that leads to type I immunity. Osteopontin has been implicated as an important factor in bone remodeling. Specifically, research suggests it plays a role in anchoring osteoclasts to the mineral matrix of bones. The fact that Osteopontin interacts with multiple cell surface receptors which are ubiquitously expressed makes it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation and ischemia. Therefore, manipulation of plasma Osteopontin levels may be useful in the treatment of autoimmune diseases, cancer metastasis, osteoporosis and some forms of stress.
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