LIFR / CD118抗体

LIFR / CD118抗体产品信息免疫原 : Recombinant mouse LIFR protein ( Catalog#50423-M08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse LIFR ( rM LIFR ; Catalog#50423-M08H ; NP_038612.1 ; Met 1 - Ser 828 ). Total IgG was purified by Protein A affinity chromatography
LIFR / CD118抗体背景综述
Mouse Leukemia inhibitory factor receptor, also known as LIF receptor, CD118 and LIFR, is single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 2 subfamily. LIFR contains six fibronectin type-III domains. LIFR is a signal-transducing molecule. It may have a common pathway with IL6ST. LIFR is the receptor for leukemia inhibitory factor (LIF), a pleiotropic cytokine affecting the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. The soluble form of LIFR inhibits the biological activity of LIF by blocking its binding to receptors on target cells. LIF action appears to be mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an α subunit that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex. The gp130 subunit was first described as the signal transducing subunit of the high-affinity IL-6 receptor complex. Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.
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