- 询价
- Abcam
- 中国/美国/德国
- xy11226-RP01
- 2025年07月15日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
OSMR / IL31RB抗体
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human OSMR / IL31RB ( rh OSMR ; Catalog#11226-H08H ; NP_003990.1 ; Met 1 - Met 740 ). Total IgG was purified by Protein A affinity chromatography.
OSMR / IL31RB抗体背景综述
Oncostatin-M-specific receptor subunit beta, also known as interleukin-31 receptor subunit beta, and OSMR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 2 subfamily. OSMR contains four fibronectin type-III domains and is expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines. Four forms of OSMR have been identified: leukemia inhibitory factor receptor (LIFR), OSMR beta, short-form OSMR (OSMRs) and soluble OSMR (sOSMR). OSMR associates with IL31RA to form the IL31 receptor. It binds IL31 to activate STAT3 and possibly STAT1 and STAT5. OSMR is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and transcription factors of the signal transducers and activators of transcription (STAT) family. Defects in OSMR are the cause of amyloidosis type 9 (AMYL9) which is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition.
OSMR / IL31RB抗体相关产品如下：xy-8248R CUTA乙酰胆碱酯酶相关蛋白抗体
xy-8139R CCDC83卷曲螺旋结构域蛋白83抗体
xy-8283R CRMP5二氢嘧啶酶相关蛋白5抗体
xy-8284R Phospho-CRMP2 (Thr514+Ser518)磷酸化二氢嘧啶酶样2抗体
xy-8285R CRMP4脑衰蛋白反应调节蛋白4抗体
xy-8140R CCDC87卷曲螺旋结构域蛋白87抗体
xy-8142R CCDC92卷曲螺旋结构域蛋白92抗体
xy-8148R CHCHD8卷曲螺旋结构域蛋白CHCHD8抗体
xy-8141R CCDC88B大脑亮氨酸拉链结构域蛋白抗体
xy-8143R CCDC93卷曲螺旋结构域蛋白93抗体
xy-8144R CCDC96卷曲螺旋结构域蛋白96抗体
xy-8145R CHCHD5卷曲螺旋结构域蛋白CHCHD5抗体
xy-8167R CHCHD6卷曲螺旋结构域蛋白CHCHD6抗体
xy-8146R CHCHD6卷曲螺旋结构域蛋白CHCHD6抗体
xy-7858R CEND1细胞周期通道和神经细胞分化蛋白1抗体
xy-8033R COLEC10(liver)凝集蛋白家族10抗体（肝）
xy-8036R COMMD7铜代谢结构域蛋白7抗体
xy-8037R COMMD4COMM结构域蛋白4抗体
xy-8031R COBLL1Cordon bleu蛋白样1抗体
xy-8032R COLEC11凝集蛋白家族11抗体
xy-8034R COMMD1铜代谢结构域蛋白1抗体
xy-15120R C20orf96 20号染色体开放阅读框96抗体
xy-15171R C3orf263号染色体开放阅读框26抗体
xy-8246R CADM2细胞粘附分子2抗体
xy-8247R COBL耳聋-甲状腺肿综合征相关COBL蛋白抗体
xy-9698R C20orf19520号染色体开放阅读框195抗体
xy-15277R C7orf627号染色体开放阅读框62抗体
xy-9490R C9orf1749号染色体开放阅读框174抗体
xy-9529R C6orf646号染色体开放阅读框64抗体
xy-4991R CD32免疫球蛋白G Fc段受体Ⅱ抗体
xy-4736R CD168透明质酸介导细胞游走受体抗体
xy-7889R CCNYL1周期素样Y1抗体
xy-7890R Cyclin J周期素J抗体
xy-7888R Cyclin L周期素L抗体
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验, YWHAZ. Cell Cycle Proteins Regulated by the Erk1/2 Pathway: CCNA1, CCNA2, CCNB1, CCNB2, CCND1, CCND2, CCND3, CCNE1, CCNE2, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1. 2。T细胞与B细胞活化基因芯片 T细胞与B细胞活化基因芯片列有适应性免疫
能阴断IL-6、IL-11两种细胞因子分别诱导的TF1细胞的增殖，而抗IL-5R只能阴断IL-6诱导的TF1的增殖，表明IL-6、IL-11受体共用一个信号转导链。OSM受体存在着低亲和力及高亲和力两种受体，低亲和力受体即gp130，gp130与LIFR构成高亲和力受体。与在IL-6R、IL-11R中不同，gp130在OSMR中只形成低亲和力受体且不能单独转导细胞因子信号。高亲和力的LIF受体由LIFR和gp130组成，OSM与LIF能竞争结合高亲和力LIF受体，但不竞争结合低亲和力的LIF受体
中性肽链内切酶，水解脑啡肽、趋化肽和P物质 CD11a MHM24,2F12;CRIS-3 Leu LFA-1(gp180/95)的α链 与ICAM-1（CD54）和ICAM-2（CD102）结合 CD11b Mol,OKM1; (Mac-1,CR
技术资料暂无技术资料 索取技术资料
