ANPEP / CD13抗体

ANPEP / CD13抗体产品信息免疫原 : Recombinant human ANPEP protein ( Catalog#10051-H08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human ANPEP ( rh ANPEP ; Catalog #10051-H08H ; NP_001141.2 ; Lys 69 - Lys 967 ). Total IgG was purified by Protein A affinity chromatography
ANPEP / CD13抗体背景综述
The human aminopeptidase N (APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. APN plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases and is involved in the metabolism of regulatory peptides by diverse cell types. CD13/APN is a potent regulator of angiogenesis which is essential for tumor invasion and metastasis, and its transcription in activated endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway. In addition, this enzyme has been shown to participate in antigen processing and presentation, and accordingly, defects in this gene appear to be a cause of various types of leukemia or lymphoma and carcinomas. Furthermore, human APN is a receptor for one strain of human coronavirus strain HCV-229E that is an important cause of upper respiratory tract infections
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