IL12A / NKSF1抗体

IL12A / NKSF1抗体产品信息免疫原 : Recombinant human IL12A protein ( Catalog#10021-H08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human IL12A ( rh IL12A ; Catalog#10021-H08H ; NP_000873.2 ; Met 1 - Ser 219 ). Total IgG was purified by Protein A affinity chromatography
IL12A / NKSF1抗体背景综述
Interleukin-12 ( IL-12 ), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a 70 kDa disulfide-linked heterodimeric cytokine composed of a 35-kD subunit P35 and a 40-kD subunit P40, also designated as IL12A and IL12B. IL12 is predominantly produced by macrophages and B lymphocytes and plays an important role in the activities of natural killer cells and T lymphocytes. IL12 is involved in the differentiation and development of Th1 cells, enhancement of natural killer cytolytic function and mitogenic effects, as well as induction of IFN-gamma during which it can synergize with other IFN-gamma inducers. The most powerful inducers of IL-12 production are bacteria, bacterial products and parasites. IL12A shows significant sequence similarity to IL-6, G-CSF, and exerts biological activities only when the IL12B is co-expressed. IL12B deficient mice are resistant to the induction of experimental chronic inflammatory diseases whereas IL12A knock-out mice develop more severe forms, suggesting opposite functions of the two subunits in the outcome of chronic inflammatory diseases.
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