SerpinE1 / PLANH1 / PAI1抗体

Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1000 serpins have been identified.

Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SERPINE1 and PLANH1, is a secreted protein which belongs to the serpin family. SERPINE1 acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SERPINE1 defect in the plasma. High concentrations of SERPINE1 have been associated with thrombophilia which is an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis
SerpinE1 / PLANH1 / PAI1抗体相关产品如下：xy-9295R ANKRD17锚蛋白重复结构域蛋白17抗体
xy-6509R ALDH1A1胞质乙醛脱氢酶1抗体
xy-6162R ARL3ADP核糖基化样因子ARL3抗体
xy-6505R 15 Lipoxygenase 1花生四烯酸15脂氧合酶1抗体
xy-6515R ABC2乳腺癌增强蛋白2抗体
xy-6512R Alpha 1 microglobulinα1微球蛋白抗体
xy-4651R Alpha B Crystallinα晶状体球蛋白B/αB-crystallin抗体
xy-5900R ADORA2B腺苷A2b受体/神经生长因子1受体抗体
xy-6251R ARK5AMPK的相关蛋白激酶5抗体
xy-5927R ANP32C致瘤磷蛋白32相关蛋白1抗体
xy-6654R Adenosine deaminase腺苷脱氨酶抗体
xy-9130R ASB4含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族4抗体
xy-11504R ATRNL1ATRNL1蛋白抗体
xy-10081R AFP4aAFP4a蛋白抗体
xy-11627R APBB2铁蛋白Fe65样蛋白1抗体
xy-11637R APBB3铁蛋白Fe65样蛋白2抗体
xy-11639R APPBP2β淀粉样蛋白前体蛋白结合蛋白2抗体
xy-11640R Aph-1b早老素稳定因子样蛋白/γ分泌酶组件蛋白APH1抗体
xy-10133R phospho-AKT1 (Tyr474)磷酸化蛋白激酶AKT1抗体
xy-10134R phospho-AKT1 (Ser473 + Tyr474)磷酸化蛋白激酶AKT1抗体
xy-11866R ASH1LASH1L蛋白抗体
xy-12040R ADRA2Cα2C-AR肾上腺素能受体抗体
xy-12977R AZI1中心体蛋白AZI1抗体
xy-7857R ALPK3α蛋白激酶3抗体（心肌）
xy-7856R ALOXE3表皮型脂氧合酶3抗体（鱼鳞病相关蛋白）
xy-7926R ANKRD28锚蛋白重复域28抗体
xy-7886R AFF4淋巴细胞相关AF4样蛋白抗体
xy-7962R ANKRD12锚蛋白重复结构域蛋白12抗体
xy-7963R ANKRD13A锚蛋白重复结构域蛋白13A抗体
xy-7964R ANKRD9锚蛋白重复结构域蛋白9抗体
xy-7966R ANKS1A锚蛋白重复及SAM结构域蛋白1A抗体
xy-7965R APM2脂肪特定转录因子2抗体
xy-7967R APOL3载脂蛋白L3抗体
xy-7969R ARMC3 (Cancer/testis antigen 81)肿瘤/睾丸抗原81抗体
xy-7976R ATXN7L2共济失调蛋白7样2抗体
xy-7970R ARS2盐耐药蛋白ARS2抗体
xy-7971R ARSA芳香基硫酸酯酶1抗体
xy-7972R ASNA1盐转运三磷酸腺苷酶抗体
xy-7973R ATE1精氨酸tRNA的蛋白转移酶1抗体
xy-7975R ATXN7L1共济失调蛋白7样1抗体
xy-6915R AUTS2孤独症易感基因2蛋白抗体（自闭症相关蛋白1）
xy-7974R ATX2脊髓小脑共济失调2型蛋白抗体
xy-9101R ARSH芳香基硫酸酯酶H抗体