CTSA / Cathepsin-A / PPGB抗体

CTSA / Cathepsin-A / PPGB抗体产品信息免疫原 : Recombinant human CTSA protein ( Catalog#10482-H08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human CTSA ( rh CTSA ; Catalog#10482-H08H ; NP_001121167.1 ; Met 1 - Tyr 480 ). CTSA specific IgG was purified by human CTSA affinity chromatography
CTSA / Cathepsin-A / PPGB抗体背景综述
Cathepsin A / lyososomal carboxypeptidase A, is a lysosomal serine protease with structural homology to yeast carboxypeptidase Y. The enzyme is synthesized as a 54kDa precursor/zymogen and processed into a catalytically active 32 and 20kDa two-chain form. linked by disulfide bonds. In addition to its carboxypeptidase activities at acidic pH, cathepsin A also serves as a multicatalytic enzyme with deamidase and esterase activities at neutral pH. Also identified as a lyososomal protective protein distinct from its catalytic function., cathepsin A associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers, and provides a protective role for stability and activity. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. It has been shown that the cathepsin A precursor has the potential to restore both beta-galactosidase and neuraminidase activities in vivo. Additionally, extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions because of its hydrolyzation activity.
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